Population genetics phd thesis word
Duffy, Craig William The population genetics and genomics of the African Salivarian trypanosomes. PhD thesis, University of Glasgow. The African Salivarian trypanosomes are the causative agents of both Human African Trypanosomiasis, or sleeping sickness, and Animal African Trypanosomiasis, more widely known population genetics phd thesis word Nagana.
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Primarily spread through the tsetse fly vector read article diseases are distributed across the sub-Saharan word belt, afflicting some of the poorest communities phd thesis word the world. Three species of trypanosomes are predominantly responsible for these two diseases.
The animal infective species T. A crucial component in understanding the diseases caused by these parasites is through understanding the diversity present in word field, as phd thesis word is ultimately the combination of host, vector and parasite diversity word gives rises to the disease phenotypes observed during clinical population genetics and treatment.
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In order to truly understand the role of such diversity in the field it is necessary to know how individuals within a population interact with one another, if they do at all. Mating between individuals allows for the direct interaction of genomes, allowing for the phd thesis word of new chromosomal sequences through meiotic recombination and new thesis word pairings through bi-parental inheritance of genetic material.
Identified phd thesis word a non-obligatory process in T. In order to further investigate the genetic population genetics and role of mating in the trypanosomes thesis word from The Gambia, Uganda and Malawi have been examined through the use of microsatellite markers specific to the genomes of T.
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The population genetics and genomics of the African Salivarian trypanosomes - Enlighten: Theses
The /how-to-write-your-essay-for-college-admission-karachi.html presented here demonstrate drastically different levels population genetics phd thesis word diversity in the respective populations and evidence for a spectrum of genetic exchange, with phd /bad-writing-essay-pdf.html highly clonal and frequently mating thesis word identified in this manner.
These population genetics phd thesis word, which closely resemble those observed for T. The apparent dominant clonality of T. That this evidence originated from the same sample sets used in the T. The final half of this thesis has focused upon the population genetics and genomics of T.
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Examination of five of T. The Ugandan populations are dominated by clonality; with repeated bottlenecks reducing the genetic diversity present as the parasites has spread northwards. The Malawi population, genetically distinct from the populations of Uganda, instead appears to favour genetic exchange over clonality, with a genetically diverse population and only a limited number of repeated genotypes. This provides the first phd thesis word of mating playing a click here role in a field population of population genetics infective trypanosomes, introducing a significant role for population genetics recombination and chromosomal reassortment which may drastically alter the way in which these parasites respond phd thesis word selective read more and evolutionary forces.
The population genetics and genomics of the African Salivarian trypanosomes
Finally, this thesis has aimed to bridge the gap between traditional low resolution studies and population genetics phd thesis word developing field see more genomics by examining the SNP variation present between three thesis word strains of T.
Utilising these data, and through sequencing of thesis word generated in the process of constructing the TREU genetic map, it has been possible population genetics phd thesis word partially reassemble the haplotypes for the megabase chromosomes of this strain, previously selected as the T.
Collected together these data provide an important resource of genomic variation for thesis word laboratory studies and as a baseline for future investigations into the genomic diversity population genetics phd field populations. In summary this thesis has demonstrated thesis word variable nature and versatile role of genetic exchange in the trypanosomes, bringing together data not only from the human infective sub-species of T.
Finally in looking to population genetics phd future this work has begun the process of transitioning from the population genetics phd thesis word low cramster facebook login microsatellite markers by examining high density SNP variation in common laboratory strains, the first step towards future adoption of these markers for the purpose of population genomics.
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